I'm entirely unconvinced "divine interpretation" can work in general as an endeavour, but that's a different topic.

1 Samuel 15 Samuel also said to Saul, “The Lord sent me to anoint you king over His people, over Israel. Now therefore, heed the voice of the words of the Lord. 2 Thus says the Lord of hosts: ‘I will punish Amalek for what he did to Israel, how he ambushed him on the way when he came up from Egypt. 3 Now go and attack Amalek, and utterly destroy all that they have, and do not spare them. But kill both man and woman, infant and nursing child, ox and sheep, camel and donkey.’”

This is not troubling to me; Christ says that He creates the wicked for destruction, in order to show His wrath. The infants and little girls have souls; they get destroyed forever in the lake of fire. What they don't have is "free will" -- that is, the ability to act outside of God's will.

Genesis 18:22 Then the men turned away from there and went toward Sodom, but Abraham still stood before the Lord. 23 And Abraham came near and said, “Would You also destroy the righteous with the wicked? 24 Suppose there were fifty righteous within the city; would You also destroy the place and not spare it for the fifty righteous that were in it? 25 Far be it from You to do such a thing as this, to slay the righteous with the wicked, so that the righteous should be as the wicked; far be it from You! Shall not the Judge of all the earth do right?”

26 So the Lord said, “If I find in Sodom fifty righteous within the city, then I will spare all the place for their sakes.”

27 Then Abraham answered and said, “Indeed now, I who am but dust and ashes have taken it upon myself to speak to the Lord: 28 Suppose there were five less than the fifty righteous; would You destroy all of the city for lack of five?”

So He said, “If I find there forty-five, I will not destroy it.”

29 And he spoke to Him yet again and said, “Suppose there should be forty found there?”

So He said, “I will not do it for the sake of forty.”

30 Then he said, “Let not the Lord be angry, and I will speak: Suppose thirty should be found there?”

So He said, “I will not do it if I find thirty there.”

31 And he said, “Indeed now, I have taken it upon myself to speak to the Lord: Suppose twenty should be found there?”

So He said, “I will not destroy it for the sake of twenty.”

32 Then he said, “Let not the Lord be angry, and I will speak but once more: Suppose ten should be found there?”

And He said, “I will not destroy it for the sake of ten.” 33 So the Lord went His way as soon as He had finished speaking with Abraham; and Abraham returned to his place.

The city is destroyed after Lot's family escapes. His wife dies in the process because she disobeyed God by looking back. That's all it takes to be wicked. The little girls need only to lack belief in order to deserve death.